CLINICAL STUDIES

Our R&D follows scientific best practices by collaborating with leading medical universities and publishing study results in medical journals.

OUR RESEARCH

0.1. Clinically Proven Results.

Tomorrowlabs brings together modern research and aesthetics with science-backed cosmetic products that actually work. We dedicate ourselves to the development of innovative products based on groundbreaking findings in regenerative medicine. True to its roots as a biotech company, Tomorrowlabs publishes its study results in leading medical journals to ensure objectivity via peer-review.

0.2. Anti-aging effects of HSF.

The joint-study “A single-center blinded randomized clinical trial to evaluate the anti-aging effects of HSF-based skin care” is a dermatologist-controlled, 6-week split-face study published in the Journal of Cosmetic Dermatology in April 2020. It included researchers from the Technical University of Munich, Johannes Kepler University, Stanford University, University of Pittsburgh, and University of Florida.

The study used FOITS 3D-analysis, which is regarded as the most advanced standard of anti-aging efficacy assessment. After 6 weeks of treatment this method confirmed a visual rejuvenation to the extent of 2.8 years. The clinical evaluation by a panel of dermatologists and plastic surgeons showed a significant reduction of wrinkles and fine lines and an increase of dermal firmness, elasticity, and moisture.

Improvements after 6 weeks

-23%
reduction in
fine wrinkles
-27%
reduction in
lip wrinkles
-22%
reduction in
crow’s feet
95%
study participant
approvement rate
+20%
improvement in
skin moisture

0.3. Preserves skin health in all skin types.

Tomorrowlabs products maintain the important barrier function of the skin and are suitable for all skin types. This is important as healthy-looking skin starts with a strong, healthy skin barrier. The skin is the largest organ in our body and protects us from viruses, bacteria, ultraviolet rays, and pollution. Especially in the case of sensitive skin prone to problems, the impairment of our skin barrier can open the door to diseases and functional disorders.

0.4. HSF effects on hereditary hair loss.

A dermatologist-controlled clinical study has been looking into the effect of HSF in the context of hereditary hair loss. In a blinded human trial over a period of 12 weeks, HSF has been shown to reduce or halt hair loss in 88% of the study participants suffering from alopecia, a maximum reduction of hair loss by 88.41%, and an average improvement of 62.1%. Considering the mean hair loss rate in healthy patients, this represents the normalization of hair turnover in individuals suffering from alopecia. The patients reported an improved look and feel.

Improvements after 12 weeks

-88%
max. improvement of
hair loss
-62%
on average
less hair lost
88%
of patients show
reduced hair loss

0.5. Examination of hair quantity and thickness.

The innovative  HSF active ingredient technology was developed based on knowledge deducted from Nobel Prize winning research and is designed to tackle hereditary hair loss at its root. In hair model studies, HSF demonstrated its growth-promoting properties in an examination of the hair follicles.3 An active ingredient complex contained in the Tomorrowlabs Hair Restoration products together with HSF targets stem cells and fibroblasts in order to improve hair growth and at the same time reduce hereditary hair loss. In a clinical investigation of 26 subjects with androgenetic alopecia the active ingredient complex led to a clinically measurable increase in hair growth and reduction in hair loss after three months of daily use.1 Over the duration of the study, its effect on hair quantity, hair thickness, hair length and the growth rate and duration of Hair growth phase (anagen phase) was examined. Tomorrowlabs HSF hair products have been specifically designed for hereditary hair loss and are skin-friendly.

Tomorrowlabs | Scienctific Articles

Skin Rejuvenation through HIF-1α Modulation
It has been demonstrated that HIF-1 is critical for cutaneous homeostasis, specifically, in the context of aging. The up-regulation of HIF-1 leads to the correction of age-dependent impairments of HIF-1 expression. This directly results in improved cutaneous regeneration and resistance to stressors such as radiation and infection. These benefits are mediated by means of positive effects on all cutaneous cell types; the upregulation of proregenerative cytokines, growth factors, and peptides; and the recruitment of circulating regenerative cells.
Plastic and Reconstructive Surgery April 2018 File:
HIF-1α-Modulation - Hoffungsvoller Ansatz für Anti-Aging Skin Care und Haarregeneration
Specialist disciplines such as plastic surgery or aesthetic dermatology have set themselves the task of delaying the aging process and maintaining a young appearance. In an increasingly well-informed society, knowledge of the principles of action and evidence of cosmetic products are of great importance. A particularly promising approach, which will have a lasting impact on the fight against age-related deficits in the skin and its appendages, is the modulation of the HIF-1α signaling pathway.
Leading Opinions Dermatologie & Plastische Chirurgie September 2019 File:
Iron Chelators & HIF-1α: A new Frontier for Skin Rejuvenation
The possibilities of a therapeutic modulation of hypoxia inducible signaling pathways by repurposing iron chelators are promising. An upregulation of HIF-1 alpha mediated by iron-chelation leads to the correction of age-dependent changes of HIF-1 expression. This directly results in improved cutaneous regeneration, as well as in resistance to exogenous stressors such as radiation and infection. These benefits are mediated through positive effects on all cutaneous cell types, the upregulation of proregenerative cytokines, growth factors and peptides, and the recruitment of circulating regenerative cells.
Regenerative Medicine in Plastic Surgery, Springer December 2019 File:
Molecular Mechanisms of Hair Growth and Regeneration – Current Understanding and Novel Paradigms
This review summarizes the current understanding of hair follicle development, repair, and regeneration, with special focus on cell signaling pathways governing these processes. In particular, we discuss emerging paradigms of molecular signaling governing the dermal papilla-epithelial cellular interactions during hair growth and maintenance and the recent progress made towards tissue engineering of human hair follicles.
Dermatology March 2020 File:
A single-center blinded randomized clinical trial to evaluate the anti-aging effects of a novel HSF-based skin care formulation
The clinical evaluation of HSF-based skin care formulation using a validated method confirmed significant improvement of wrinkles, in particular of fine wrinkles, lip wrinkles, and crow's feet. A significant skin moisturizing effect was detected while skin barrier function was preserved. A significant reduction in skin roughness could be demonstrated. No negative skin reactions of dermatological relevance were documented for the test product.
Journal of Cosmetic Dermatology April 2020 File
Deferiprone Stimulates Aged Dermal Fibroblasts via HIF-1 alpha Modulation
The activation of HIF-1 by DFP enhances cell metabolism, proliferation, and survival of fibroblasts while reducing lactate dehydrogenase levels. Modulation of HIF-1 is linked to activation of key regeneration enzymes and proteins, and by proxy, antiaging. Therefore, the antiaging properties of DFP and its satisfactory dermal penetration make it a promising regenerative agent.
Journal of Aesthetic Surgery June 2020 File:
HIF-1α Stimulators Function Equally to Leading Hair Loss Agents in Enhancing Dermal Papilla Growth
Here we demonstrate a significantly enhanced proliferative activity for both established substances against AGA (minoxidil and caffeine) and the HIF-1α-stimulating agent DFP in a 3D DPC spheroid culture model with equal results for DFP and minoxidil. These favorable characteristics make such compounds potential water-soluble alternatives to minoxidil.
Skin Pharmacology and Physiology December 2020 File:
  1. Active ingredient complex consisting of GDHQG, EGCG2, glycine and zinc. Tested on 26 male volunteers between the ages of 18 and 70 with a hair loss level of III to IV determined on the Norwood Hamilton scale. The clinical study was randomized and double-blinded in 2014 by Induchem AG and all clinical observations were made under the supervision of a dermatologist.
  2. Tested in 2015 on 4 volunteers with 10% symrise sympeptidxlash measured with CANON 5-dmii after 2, 4, 6, and 8 weeks and daily one-time application.
  3. Bukowiecki J. et al. "HIF-1α stimulators function equally to leading hair loss agents in enhancing dermal papilla growth" Under Review in Skin Pharmacology and Physiology